Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors
نویسندگان
چکیده
منابع مشابه
Hypothalamic Expression of Melanocortin-4 Receptor and Agouti-related Peptide mRNAs During the Estrous Cycle of Rats
Melanocortin- 4 receptor (MC4R) and agouti- related peptide (AgRP) are involved in energy homeostasis in rats. According to MC4R and AgRP effects on luteinizing hormone (LH) secretion, they may influence the estrous cycle of rats. Therefore, the aim of this study was to investigate the expression of MC4R and AgRP mRNAs at different stages of estrous cycle in the rat’s hypothalamus. The estrous ...
متن کاملCharacterization of Agouti-related protein binding to melanocortin receptors.
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action that is thought to play an important role in the hypothalamic control of feeding behavior. The exact mechanism of AGRP and Agouti protein action has been difficult to examine, in part because of difficulties in producing homogeneous forms of these molecules that can be used for direct binding assays. In thi...
متن کاملThe natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors.
Agouti-related protein (Agrp), one of the two naturally occurring inverse agonists known to inhibit G protein-coupled receptor activity, regulates energy expenditure by decreasing basal and blocking agonist-promoted melanocortin receptor (MCR) signaling. Here we report that, in addition to its inverse agonistic activities, Agrp exhibits agonistic properties on the endocytosis pathway of melanoc...
متن کاملhypothalamic expression of melanocortin-4 receptor and agouti-related peptide mrnas during the estrous cycle of rats
melanocortin- 4 receptor (mc4r) and agouti- related peptide (agrp) are involved in energy homeostasis in rats. according to mc4r and agrp effects on luteinizing hormone (lh) secretion, they may influence the estrous cycle of rats. therefore, the aim of this study was to investigate the expression of mc4r and agrp mrnas at different stages of estrous cycle in the rat’s hypothalamus. the estrous ...
متن کاملExpression of melanocortin-4 receptor and agouti-related peptide mRNAs in arcuate nucleus during long term malnutrition of female ovariectomized rats
Objective: Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. Materials and Methods: Ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2016
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2016.05.008